Recently we showed a significant increase of Isoprenaline-induced inotropy in TRPM4-deficient (Trpm4 −/−) mice. TRPM4 and TRPM5 proteins belong to the Transient Receptor Potential (TRP) ion channel family and form Ca 2 +-activated nonselective cation channels. Providers of emergency care should be educated about possible contraindications to its use. Ipecac has potentially adverse consequences and should not be used reflexively. EDs recommended ipecac inappropriately with a broader range of contraindications and more often in adults. The poison center recommended ipecac inappropriately less often than emergency departments and usually in children ingesting a nontoxic substance. Among children, the most common contraindication was the ingestion of a nontoxic substance or amount of substance. Among adults the most common contraindication was the ingestion of a substance known to cuase altered mental status. The most common inappropriate situation was that too much time had elapsed from the time of ingestion. In 20% of cases in which ipecac was used, its use was inappropriate. The use of ipecac was judged appropriate or inappropriate based on the consensus of three of professionals associated with the poison center using predetermined contraindications. To evaluate the use of ipecac by health care professionals.Ī descriptive case series based on a one-year review of all calls to a poison center.Ī university hospital-affiliated regional poison center. We conclude that activated charcoal is effective in inhibiting absorption of orally administered salicylate, in a small-dose aspirin ingestion model, with a three-dose multiple charcoal regimen being superior to either single-dose or two-dose regimens. There was a statistically significant decrease in salicylate absorption with the three-dose charcoal regimen as compared to one-dose and two-dose regimens ( P <. There was no significant difference between one-dose and two-dose charcoal regimens. Each charcoal treatment significantly lowered the absorption of aspirin as compared with the control ( P <. Mean ± SD percent recovery of salicylate from urine was: control, 91.0 ± 6.12 one-dose charcoal, 68.3 ± 12.46 two-dose charcoal, 65.9 ± 13.48 and three-dose charcoal, 49.2 ± 12.48. Ten subjects completed all four phases of the study. Urine was collected for 48 hours to determine percent total salicylate excretion. The control phase and treatment periods were separated by a one-week interval. Thirteen adult volunteers were each given 24 81-mg aspirin tablets during a control phase, and during three randomized treatment periods the volunteers received 50 g activated charcoal for one, two, or three doses (separated by four hours). The effects of multiple-dose activated charcoal administration on the absorption of orally administered salicylate were evaluated in a simulated overdose model.
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